Hypercalcemia in pediatric acute megakaryocytic leukemia: case report and review of the literature

J Pediatr Hematol Oncol. 2009 May;31(5):373-6. doi: 10.1097/MPH.0b013e31819a5d29.


Hypercalcemia has been described as a possible complication of many pediatric malignancies. Here, we report an 8-month-old non-Down syndrome infant with acute megakaryocytic leukemia and severe hypercalcemia at presentation. A review of the literature reveals that this is the first case of hypercalcemia complicating acute megakaryocytic leukemia reported in the pediatric literature. His initial workup, and the course of management and outcome, is described in detail. Though the etiology of this complication remains unclear, our experience suggests that early institution of chemotherapy along with supportive care is the best treatment for control of hypercalcemia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Density Conservation Agents / administration & dosage
  • Bone Diseases, Metabolic / diagnostic imaging
  • Bone Diseases, Metabolic / drug therapy
  • Bone Diseases, Metabolic / etiology
  • Diphosphonates / administration & dosage
  • Humans
  • Hypercalcemia / etiology*
  • Hypercalcemia / therapy
  • Infant
  • Leukemia, Megakaryoblastic, Acute / complications*
  • Leukemia, Megakaryoblastic, Acute / drug therapy
  • Male
  • Pamidronate
  • Radiography


  • Bone Density Conservation Agents
  • Diphosphonates
  • Pamidronate