The current study examined the hypotheses that internal health locus of control comprises multiple dimensions and that these dimensions are differentially associated with physical health status. As expected, using covariance structure modeling of data derived from 181 medical outpatients, internal health locus of control was found to be multidimensional. Predicted dimensions included recognition that illness prevention is contingent on successful execution of potential health actions, recognition that illness management is contingent on successful execution of potential health actions, and self-mastery over health outcomes (i.e., the perceived capacity to achieve desired health outcomes). A 4th dimension (i.e., self-blame for negative health outcomes) also emerged. Moreover, as predicted, only perceptions of self-mastery were independently associated with indexes of physical health and well-being.