Abnormal fetal cerebral laminar organization in cobblestone complex as seen on post-mortem MRI and DTI

Pediatr Radiol. 2009 Aug;39(8):860-4. doi: 10.1007/s00247-009-1255-0. Epub 2009 May 5.


We report a unique case of cobblestone complex using post-mortem MR and diffusion tensor imaging to assess the laminar organization of the fetal cerebrum. The imaging findings were correlated with autopsy findings. Abnormal cortical development in cobblestone complex resulted in disruption of normal laminar organization of the fetal brain, which was seen as interruption and nodularity of the high-signal T1 cortical band with increased anisotropy and medium diffusivity extending beyond the cortical band into the cerebral mantle on post-mortem MR and diffusion tensor imaging.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autopsy
  • Brain / embryology*
  • Brain / pathology*
  • Cobblestone Lissencephaly / psychology*
  • Humans
  • Magnetic Resonance Imaging*
  • Male