On the conversion of thymidine phosphate bromohydrins to thymidine phosphates: a model reaction for the repair of oxidized nucleotides

Yakugaku Zasshi. 1991 Jun;111(6):284-92. doi: 10.1248/yakushi1947.111.6_284.

Abstract

Bromohydrins (12, 13, and 14), which were oxidatively damaged products of thymidine nucleotides, were repaired by the action of sunlight (2700 lux) or heat via a radical mechanism to regenerate the original nucleotides (8,9, and 10). A significant effect of 3',5'-phosphate linkage on the repair reactions to natural type of thymidine nucleotide was proposed.

MeSH terms

  • Alcohols*
  • DNA Repair
  • Free Radicals
  • Furans
  • Hot Temperature*
  • Oxidation-Reduction
  • Solvents
  • Sunlight*
  • Thymine Nucleotides*

Substances

  • Alcohols
  • Free Radicals
  • Furans
  • Solvents
  • Thymine Nucleotides
  • bromohydrins
  • tetrahydrofuran