Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy

J Oral Pathol Med. 1991 Sep;20(8):389-91. doi: 10.1111/j.1600-0714.1991.tb00950.x.


An evaluation of the thiamine, riboflavin and pyridoxine (vitamin B1, B2 and B6) status of 60 patients with recurrent mouth ulcers was performed. Seventeen patients (28.2%) were found to be deficient in one or more of these vitamins. Replacement therapy of these vitamins was given to a study group of deficient patients and a non-deficient group for one month. At the end of therapy and after a follow-up period of 3 months, only those patients who had a B complex deficiency had a significant sustained clinical improvement in their mouth ulcers. Vitamin B1, B2 and B6 deficiencies should, therefore, be considered as another possible precipitating factor in recurrent aphthous ulceration.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Humans
  • Medical Records
  • Middle Aged
  • Prospective Studies
  • Pyridoxine / blood*
  • Pyridoxine / therapeutic use
  • Recurrence
  • Riboflavin / blood*
  • Riboflavin / therapeutic use
  • Riboflavin Deficiency / blood
  • Riboflavin Deficiency / drug therapy
  • Stomatitis, Aphthous / blood*
  • Stomatitis, Aphthous / drug therapy
  • Thiamine / blood*
  • Thiamine / therapeutic use
  • Thiamine Deficiency / blood
  • Thiamine Deficiency / drug therapy
  • Vitamin B 6 Deficiency / blood
  • Vitamin B 6 Deficiency / drug therapy


  • Pyridoxine
  • Riboflavin
  • Thiamine