Do cancer cells care if their host is hungry?

Cell Metab. 2009 May;9(5):401-3. doi: 10.1016/j.cmet.2009.04.006.

Abstract

A recent report by Kalaany and Sabatini concerning mechanisms underlying the inhibitory effect of dietary restriction on the growth of certain tumors adds to the evidence that insulin and IGF-I are hormones with relevance to oncology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AMP-Activated Protein Kinases / metabolism
  • Animals
  • Diet
  • Energy Metabolism
  • Insulin / metabolism*
  • Insulin-Like Growth Factor I / metabolism*
  • Mice
  • Neoplasms / metabolism
  • Neoplasms / prevention & control*
  • PTEN Phosphohydrolase / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • Transplantation, Heterologous

Substances

  • Insulin
  • Insulin-Like Growth Factor I
  • Phosphatidylinositol 3-Kinases
  • AMP-Activated Protein Kinases
  • PTEN Phosphohydrolase
  • Pten protein, mouse