Low dose methotrexate therapy for rheumatoid arthritis complicated by pancytopenia and Pneumocystis carinii pneumonia

J Rheumatol. 1991 Aug;18(8):1257-9.


In a patient with rheumatoid arthritis pancytopenia and Pneumocystis carinii pneumonia occurred during low dose methotrexate therapy. This case emphasizes the potential development of opportunistic infections even with low dose methotrexate. Pneumocystis carinii pneumonia resembles methotrexate induced pneumonitis. Therefore opportunistic infections should be considered before a definite diagnosis of methotrexate induced pneumonitis is made.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Aged
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Male
  • Methotrexate / adverse effects*
  • Methotrexate / therapeutic use*
  • Opportunistic Infections / chemically induced
  • Opportunistic Infections / etiology
  • Pancytopenia / chemically induced*
  • Pancytopenia / etiology
  • Pneumonia, Pneumocystis / chemically induced*
  • Pneumonia, Pneumocystis / etiology


  • Methotrexate