Stereoselective asymmetric synthesis of (+)-sedamine and (+)-allosedamine
- PMID: 19418554
- DOI: 10.1002/chir.20729
Stereoselective asymmetric synthesis of (+)-sedamine and (+)-allosedamine
Abstract
A convenient method for the generation of (+)-sedamine and (+)-allosedamine in high optical purity has been elaborated. The key steps are the highly stereoselective 1,2-nucleophilic addition to SAMP hydrazones allowing the installation of the stereogenic center at C2 and ring closing metathesis.
2009 Wiley-Liss, Inc.
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