[Metabolic rhabdomyolysis during statin therapy]

Rev Med Interne. 2009 Aug;30(8):711-3. doi: 10.1016/j.revmed.2008.10.336. Epub 2009 May 5.
[Article in French]

Abstract

The occurrence of rhabdomyolysis during statin treatment for dyslipidemia is a well-known side effect. However, the differential diagnosis of rhabdomyolysis is large. We report on a patient treated with statin who presented a rhabdomyolysis. The persistence of laboratory abnormalities allowed to discover a metabolic rhabdomyolysis, namely a carnitine palmitoyltransférase II deficiency. The diagnosis of the genetic abnormality allows to modify the therapeutic care.

Publication types

  • Case Reports

MeSH terms

  • Atorvastatin
  • Carnitine O-Palmitoyltransferase / deficiency*
  • Heptanoic Acids / adverse effects
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Male
  • Middle Aged
  • Pyridines / adverse effects
  • Pyrroles / adverse effects
  • Rhabdomyolysis / diagnosis*
  • Rhabdomyolysis / genetics*

Substances

  • Heptanoic Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyridines
  • Pyrroles
  • Atorvastatin
  • cerivastatin
  • Carnitine O-Palmitoyltransferase