The genetics of Parkinson's syndromes: a critical review

Curr Opin Genet Dev. 2009 Jun;19(3):254-65. doi: 10.1016/j.gde.2009.03.008. Epub 2009 May 4.

Abstract

Genetic analysis has identified many loci designated as PARK loci (OMIM #168600). Many of these loci do not refer to idiopathic Parkinson's disease which is characterized by Lewy body pathology, but rather to clinical parkinsonisms. In this review, besides reviewing the genetic of the disorder, we argue that this designation is misleading and that if we seek to understand the pathogenesis, we should study the genetics of Lewy body diseases: these include not only idiopathic Parkinson's disease, but also such disparate syndromes as Hallevorden-Spatz disease and Niemann-Pick Type C.

Publication types

  • Review

MeSH terms

  • F-Box Proteins / genetics
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Lewy Body Disease / genetics*
  • Lewy Body Disease / pathology
  • Mutation*
  • Parkinson Disease / genetics*
  • Parkinson Disease / pathology
  • Protein-Serine-Threonine Kinases / genetics
  • Syndrome
  • Ubiquitin-Protein Ligases / genetics
  • alpha-Synuclein / genetics

Substances

  • F-Box Proteins
  • FBXO7 protein, human
  • SNCA protein, human
  • alpha-Synuclein
  • Ubiquitin-Protein Ligases
  • parkin protein
  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Protein-Serine-Threonine Kinases