Bone tumors: osteosarcoma and Ewing's sarcoma

Curr Opin Pediatr. 2009 Jun;21(3):365-72. doi: 10.1097/MOP.0b013e32832b1111.


Purpose of review: Osteosarcoma and Ewing's sarcoma are the two most common primary malignant bone tumors in children and account for approximately 6% of all childhood malignancies. Treatment methods have seen significant advancements, particularly in regard to chemotherapy and limb-sparing surgery. These advancements have led to increased survival rate. With many long-term survivors, it is important to evaluate long-term patient outcomes following treatment, including function and health-related quality of life. We will review the current trends in treatment of these diseases, different reconstructive options available, and the methods and results for evaluating the long-term results.

Recent findings: There have been many improvements in the medical treatment of these tumors leading to increasing long-term survival. There have also been improvements in reconstructive techniques for the maintenance of functional extremities in these patients. Newer evaluation methods for both functional outcome and health-related quality of life measures that are more specific to children and adolescents are being developed and in use.

Summary: This report will provide an overview of the current treatment options and long-term complications in primary malignant bone tumors for the pediatrician caring for a child with these problems.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Bone Neoplasms* / diagnosis
  • Bone Neoplasms* / epidemiology
  • Bone Neoplasms* / therapy
  • Child
  • Combined Modality Therapy
  • Humans
  • Morbidity
  • Neoplasm Staging / methods
  • Osteosarcoma* / diagnosis
  • Osteosarcoma* / epidemiology
  • Osteosarcoma* / therapy
  • Sarcoma, Ewing* / diagnosis
  • Sarcoma, Ewing* / epidemiology
  • Sarcoma, Ewing* / therapy
  • United States / epidemiology