Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome

Scand J Med Sci Sports. 2010 Apr;20(2):282-90. doi: 10.1111/j.1600-0838.2009.00895.x. Epub 2009 Apr 13.


The aim of the current study was to investigate the levels of interleukin-6 (IL-6), its soluble receptors (sIL-6R and sgp130) and F(2)-isoprostanes, at rest and during exercise, in patients with chronic fatigue syndrome (CFS). Six male CFS patients and six healthy controls performed an incremental exercise test to exhaustion and a submaximal exercise bout to exhaustion. Blood samples taken in the submaximal test at rest, immediately post-exercise and 24 h post-exercise were analyzed for IL-6, sIL-6R, sgp130 and F(2)-isoprostanes. A further 33 CFS and 33 healthy control participants gave a resting blood sample for IL-6 and sIL-6R measurement. During the incremental exercise test only power output at the lactate threshold was lower (P<0.05) in the CFS group. F(2)-isoprostanes were higher (P<0.05) in CFS patients at rest and this difference persisted immediately and 24 h post-exercise. The exercise study found no differences in IL-6, sIL-6R or sgp130 at any time point between groups. In the larger resting group, there were no differences in IL-6 and sIL-6R between CFS and control groups. This investigation has demonstrated that patients with CFS do not have altered plasma levels of IL-6, sIL-6R or sgp130 either at rest or following exercise. F(2)-isoprostanes, however, were consistently higher in CFS patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Cytokine Receptor gp130 / blood*
  • Cytokine Receptor gp130 / metabolism
  • Exercise Test
  • F2-Isoprostanes / blood*
  • F2-Isoprostanes / metabolism
  • Fatigue Syndrome, Chronic / blood*
  • Fatigue Syndrome, Chronic / metabolism
  • Female
  • Humans
  • Interleukin-6 / blood*
  • Interleukin-6 / metabolism
  • Lactates / blood
  • Male
  • Middle Aged
  • Oxygen Consumption
  • Physical Exertion / physiology*
  • Receptors, Interleukin-6 / blood*
  • Receptors, Interleukin-6 / metabolism


  • F2-Isoprostanes
  • IL6 protein, human
  • IL6R protein, human
  • IL6ST protein, human
  • Interleukin-6
  • Lactates
  • Receptors, Interleukin-6
  • Cytokine Receptor gp130