Abstract
A series of novel ether-linked bis(heterocycle)s have been synthesized via [3+2]-cycloaddition reaction of nitrile oxide with allyl alcohol followed by intramolecular 1,3-diploar cycloaddition reaction of nitrile imine with carbonyl group. All the newly synthesized compounds were screened for their anti-inflammatory and analgesic activities. Among the list of compounds (7a-k) studied, 7d, 7g, 7j, and 7k exhibited excellent activity comparable to ibuprofen and aspirin at the similar dosages.
MeSH terms
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Analgesics / chemical synthesis
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Analgesics / chemistry*
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Analgesics / therapeutic use*
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Animals
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Anti-Inflammatory Agents / chemical synthesis
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / therapeutic use*
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Edema / chemically induced
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Edema / drug therapy
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Female
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Male
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Mice
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Molecular Structure
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Oxadiazoles / chemical synthesis
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Oxadiazoles / chemistry*
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Oxadiazoles / therapeutic use*
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Pain Measurement / drug effects
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Rats
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Stomach / drug effects
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Structure-Activity Relationship
Substances
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Analgesics
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Anti-Inflammatory Agents
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Oxadiazoles