Mesenchymal stem cells in the induction of transplantation tolerance

Transplantation. 2009 May 15;87(9 Suppl):S55-7. doi: 10.1097/TP.0b013e3181a287e6.


Mesenchymal stem cells directly suppress ongoing immune responses. Through production of toleragenic cytokines, inhibition of lymphocyte proliferation, delivery of reparative and protective signals after reperfusion injury, and facilitation of hematopoietic chimerism, these cells demonstrate a wide-ranging potential for the development of multifaceted toleragenic strategies after transplantation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • B-Lymphocytes / immunology
  • Cell Transformation, Neoplastic / immunology
  • Dendritic Cells / immunology
  • Humans
  • Immune Tolerance*
  • Immunosuppression
  • Killer Cells, Natural / immunology
  • Lymphocyte Activation
  • Mesenchymal Stem Cell Transplantation / methods*
  • Mesenchymal Stem Cells / immunology*
  • T-Lymphocytes / immunology
  • T-Lymphocytes, Regulatory / immunology
  • Transplantation Chimera
  • Transplantation Tolerance* / immunology