Interleukin-17A is not expressed by CD207(+) cells in Langerhans cell histiocytosis lesions

Nat Med. 2009 May;15(5):483-4; author reply 484-5. doi: 10.1038/nm0509-483.


Interleukin-17 (IL-17A) is a pro-inflammatory cytokine that has recently been implicated in pathogenesis of Langerhans Cell Histiocytosis (LCH), a potentially fatal disease characterized by lesions including CD207+ (langerin +) histiocytes. However, in this study we were unable to identify IL-17A gene expression in Langerhans cell lesions, and plasma levels of IL-17A did not correlate with disease activity. Therefore, this study does not support a central role for IL-17A in LCH pathogenesis.

Publication types

  • Comment
  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / metabolism*
  • Biopsy
  • Cell Division
  • Cell Survival
  • Dendritic Cells / pathology
  • Enzyme-Linked Immunosorbent Assay
  • Gene Amplification
  • Gene Expression Regulation
  • Histiocytosis, Langerhans-Cell / pathology
  • Histiocytosis, Langerhans-Cell / physiopathology*
  • Humans
  • Interleukin-17 / blood
  • Interleukin-17 / genetics*
  • Lectins, C-Type / metabolism*
  • Mannose-Binding Lectins / metabolism*
  • Polymerase Chain Reaction


  • Antigens, CD
  • CD207 protein, human
  • Interleukin-17
  • Lectins, C-Type
  • Mannose-Binding Lectins