Chronic basophilic leukemia: a rare form of chronic myeloproliferative neoplasm

Hum Pathol. 2009 Aug;40(8):1194-9. doi: 10.1016/j.humpath.2009.02.011. Epub 2009 May 8.

Abstract

Chronic basophilic leukemia is a rare and poorly characterized entity. Only a limited number of cases have been described. Herein, we report a patient who presented with fatigue, weight loss, leukocytosis, persistent prominent basophilia, and mild eosinophilia. The bone marrow showed features characteristic of a myeloproliferative neoplasm with a marked increase in maturing basophils. The basophils exhibited nuclear hypersegmentation, abnormal granulation, and abnormally low CD38 expression. Conventional karyotyping revealed a t(5;12)(q31;p13). ETV6 but not PDGFRB rearrangement was detected by fluorescence in situ hybridization.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Basophils / pathology*
  • Bone Marrow Cells / pathology
  • Cell Nucleus / pathology
  • Chromosomes, Human, Pair 12
  • Chromosomes, Human, Pair 5
  • Flow Cytometry
  • Gene Rearrangement
  • Humans
  • Immunophenotyping
  • In Situ Hybridization, Fluorescence
  • Leukemia, Myeloid, Chronic-Phase / genetics
  • Leukemia, Myeloid, Chronic-Phase / pathology*
  • Male
  • Proto-Oncogene Proteins c-ets / genetics
  • Repressor Proteins / genetics
  • Translocation, Genetic / genetics

Substances

  • ETS translocation variant 6 protein
  • Proto-Oncogene Proteins c-ets
  • Repressor Proteins