Laterality of neocortical slow-wave oscillations in anesthetized mice

Neurosci Res. 2009 Jun;64(2):240-2. doi: 10.1016/j.neures.2009.02.006. Epub 2009 Feb 25.


In the slow-wave (SW) state, the vast majority of cortical neurons exhibit mostly synchronized oscillatory activity. In this study, we examined the right-left hemispheric difference in slow-wave timings in urethane-anesthetized mice. We found that interhemispheric cross-correlograms of local field potentials (LFPs) peaked asymmetrically. Double in vivo whole-cell patch-clamp recordings also revealed the interhemispheric temporal disparity of slow wave-relevant synaptic barrages. The data suggest the hemispheric laterality in the slow wave origin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Anesthesia
  • Animals
  • Frontal Lobe / physiology
  • Functional Laterality*
  • Male
  • Mice
  • Neocortex / physiology*
  • Neurons / physiology
  • Occipital Lobe / physiology
  • Parietal Lobe / physiology
  • Patch-Clamp Techniques
  • Sleep Stages / physiology
  • Synapses / physiology