Phactr2 and Parkinson's disease

Neurosci Lett. 2009 Mar 27;453(1):9-11. doi: 10.1016/j.neulet.2009.02.009. Epub 2009 Feb 10.


Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P=0.032), Canadian (OR: 1.41, P=0.014) and Irish (OR: 1.44, P=0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P=0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P<0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Canada / epidemiology
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Ireland / epidemiology
  • Male
  • Microfilament Proteins / genetics*
  • Middle Aged
  • Nerve Tissue Proteins / genetics*
  • Norway / epidemiology
  • Parkinson Disease / epidemiology
  • Parkinson Disease / genetics*
  • Polymorphism, Single Nucleotide*
  • Risk Factors
  • United States / epidemiology
  • Young Adult


  • Microfilament Proteins
  • Nerve Tissue Proteins
  • Phactr2 protein, human