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Review
, 19 (8), 816-28

Protein O-mannosylation: Conserved From Bacteria to Humans

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Review

Protein O-mannosylation: Conserved From Bacteria to Humans

Mark Lommel et al. Glycobiology.

Abstract

Protein O-mannosylation is an essential modification in fungi and animals. Different from most other types of O-glycosylation, protein O-mannosylation is initiated in the endoplasmic reticulum by the transfer of mannose from dolichol monophosphate-activated mannose to serine and threonine residues of secretory proteins. In recent years, it has emerged that even bacteria are capable of O-mannosylation and that the biosynthetic pathway of O-mannosyl glycans is conserved between pro- and eukaryotes. In this review, we summarize the observations that have opened up the field and highlight characteristics of O-mannosylation in the different domains/kingdoms of life.

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