Effect of silicon gel sheeting in nasal injury associated with nasal CPAP in preterm infants

Indian Pediatr. 2010 Mar;47(3):265-7. doi: 10.1007/s13312-010-0047-9. Epub 2009 Apr 15.


We conducted this study to investigate the efficacy of the silicon gel application on the nares in prevention of nasal injury in preterm infants ventilated with nasal continuous positive airway pressure (NCPAP). Patients (n=179) were randomized into two groups: Group 1 (n=87) had no silicon gel applied to nares, and in Group 2 (n=92), the silicon gel sheeting was used on the surface of nares during ventilation with NCPAP. Nasal injury developed in 13 (14.9%) neonates in Group 1 and 4 (4.3%) newborns in Group 2 (OR:3.43; 95% CI: 1.1-10.1; P<0.05). The incidence of columella necrosis was also significantly higher in the Group 1 (OR: 6.34; 95% CI: 0.78-51.6; P<0.05). We conclude that the silicon gel application may reduce the incidence and the severity of nasal injury in preterm infants on nasal CPAP.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Continuous Positive Airway Pressure / adverse effects
  • Continuous Positive Airway Pressure / methods*
  • Gels
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Necrosis
  • Nose / injuries*
  • Prospective Studies
  • Silicon / administration & dosage*
  • Wounds and Injuries / etiology
  • Wounds and Injuries / prevention & control


  • Gels
  • Silicon