High-temperature, but not high-pressure, conditions alter neuronal activity

J Pharmacol Sci. 2009 May;110(1):117-21. doi: 10.1254/jphs.09031sc. Epub 2009 May 9.

Abstract

We describe the effect of high pressure and high temperature on neuronal activity. Increased intracranial pressure is generally a pathological sign observed in intracerebral hemorrhage, brain edema, and brain tumor, yet little is known about how the hyperbaric pressure per se affects neuronal activity. Using a pressure/temperature-changeable perfusion chamber, we carried out functional multineuron calcium imaging to record spontaneous spiking activity simultaneously from about 100 neurons in hippocampal slice cultures. High-pressure conditions (up to 100 mmHg) did not alter the network excitability, whereas high-temperature conditions (up to 40 degrees C) increased synchronized network activity. Thus, neurons are sensitive to feverish conditions, but the acute hyperbaric circumstance itself is unlikely to exert a detrimental effect on neuronal function.

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Calcium Signaling / physiology
  • Hippocampus / cytology
  • Hippocampus / physiology
  • Hot Temperature*
  • In Vitro Techniques
  • Intracranial Pressure / physiology
  • Nerve Net / cytology
  • Nerve Net / drug effects
  • Neurons / physiology*
  • Pressure*
  • Rats
  • Rats, Wistar