Bullosis diabeticorum associated with a prediabetic state

South Med J. 2009 Jun;102(6):643-4. doi: 10.1097/SMJ.0b013e3181a506d6.


Bullosis diabeticorum, or diabetic bullae, is a non-inflammatory blistering condition that is virtually diagnostic of diabetes. Diabetic bullae most often present as painless, tense, superficial bullae that occur in an acral distribution and commonly heal in 2-6 weeks without scarring, but complications such as secondary bacterial infection or hemorrhage may occur. The diagnosis of bullosis diabeticorum in a nondiabetic patient should prompt screening for diabetes. A case of recurrent bullae in a prediabetic patient is presented, with a review of the clinical features and significance of bullosis diabeticorum.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Blood Glucose / analysis
  • Female
  • Humans
  • Prediabetic State / complications*
  • Prediabetic State / diagnosis
  • Prediabetic State / pathology
  • Skin / pathology
  • Skin Diseases, Vesiculobullous / diagnosis
  • Skin Diseases, Vesiculobullous / etiology*
  • Skin Diseases, Vesiculobullous / pathology


  • Blood Glucose