Stimulatory action of calcium L-threonate on ascorbic acid uptake by a human T-lymphoma cell line

Life Sci. 1991;49(19):1377-81. doi: 10.1016/0024-3205(91)90388-r.


The effects of preincubation of human T-lymphoma cells with increasing concentrations of calcium L-threonate on the uptake of L-[1-14C]ascorbic acid were examined. Calcium L-threonate (0-1,000 mg%) stimulated ascorbic acid (1.25 mg%) uptake in a dose-dependent manner. These results indicate that calcium threonate and possibly other ascorbic acid metabolites have biological activity and potential pharmacological applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Ascorbic Acid / pharmacokinetics*
  • Butyrates / pharmacology*
  • Dose-Response Relationship, Drug
  • Humans
  • Lymphoma, T-Cell / metabolism*
  • Tumor Cells, Cultured / metabolism


  • Butyrates
  • threonic acid
  • Ascorbic Acid