Pharmacological approaches to modifying HDL: more basic science to understand HDL metabolism is necessary. Editorial to: "NO-1886 up-regulates Niemann-Pick C1 protein (NPC1) expression through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells" by Xin Ma et al

Cardiovasc Drugs Ther. 2009 Jun;23(3):187-8. doi: 10.1007/s10557-009-6171-x.
No abstract available

Publication types

  • Editorial
  • Comment

MeSH terms

  • Atherosclerosis / metabolism*
  • Benzamides / pharmacology*
  • Carrier Proteins / biosynthesis*
  • Cholesterol, HDL / blood
  • Cholesterol, HDL / metabolism*
  • DNA-Binding Proteins / physiology*
  • Foam Cells / drug effects
  • Foam Cells / metabolism
  • Humans
  • Hypolipidemic Agents / pharmacology*
  • Intracellular Signaling Peptides and Proteins
  • Liver X Receptors
  • Membrane Glycoproteins / biosynthesis*
  • Niemann-Pick C1 Protein
  • Organophosphorus Compounds / pharmacology*
  • Orphan Nuclear Receptors
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Up-Regulation

Substances

  • Benzamides
  • Carrier Proteins
  • Cholesterol, HDL
  • DNA-Binding Proteins
  • Hypolipidemic Agents
  • Intracellular Signaling Peptides and Proteins
  • Liver X Receptors
  • Membrane Glycoproteins
  • NPC1 protein, human
  • NR1H3 protein, human
  • Niemann-Pick C1 Protein
  • Organophosphorus Compounds
  • Orphan Nuclear Receptors
  • Receptors, Cytoplasmic and Nuclear
  • 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide