Inducible cAMP early repressor (ICER) and brain functions

Mol Neurobiol. 2009 Aug;40(1):73-86. doi: 10.1007/s12035-009-8072-1. Epub 2009 May 13.


The inducible cAMP early repressor (ICER) is an endogenous repressor of cAMP-responsive element (CRE)-mediated gene transcription and belongs to the CRE-binding protein (CREB)/CRE modulator (CREM)/activating transcription factor 1 (ATF-1) gene family. ICER plays an important role in regulating the neuroendocrine system and the circadian rhythm. Other aspects of ICER function have recently attracted heightened attention. Being a natural inducible CREB antagonist, and more broadly, an inducible repressor of CRE-mediated gene transcription, ICER regulates long-lasting plastic changes that occur in the brain in response to incoming stimulation. This review will bring together data on ICER and its functions in the brain, with a special emphasis on recent findings highlighting the involvement of ICER in the regulation of long-term plasticity underlying learning and memory.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / physiology*
  • Cyclic AMP Response Element Modulator / physiology*
  • Cyclic AMP Response Element-Binding Protein / metabolism
  • Gene Expression Regulation
  • Humans
  • Learning / physiology
  • Memory / physiology
  • Neuronal Plasticity


  • Cyclic AMP Response Element-Binding Protein
  • Cyclic AMP Response Element Modulator