The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats

Life Sci. 1991;49(23):PL189-94. doi: 10.1016/0024-3205(91)90321-2.

Abstract

Zinc compounds have been shown to antagonize various types of gastric ulceration in rats. Zinc carnosine (Z-103), a newly developed agent was, therefore, examined for its antiulcer effect in stress-induced ulceration and also its membrane stabilizing action in rat stomachs. Cold-restraint (restrained at 4 degrees C for 2 h) stress induced severe hemorrhagic lesions together with increased mast cell degranulation and beta-glucuronidase release in the gastric glandular mucosa. Z-103 pretreatment with a single oral dose (3, 10 or 30 mg/kg) reversed these actions in a dose-dependent manner. When the compound was incubated in concentrations of 10(-7, 10(-6), 10(-5) or 10(-4) M, with isolated hepatic lysosomes, it significantly reduced the spontaneous release of beta-glucuronidase in the medium. The present study not only demonstrates the antiulcer effect of Z-103 but also indicates that the protective action is likely to be mediated by its membrane-stabilizing action on mast cells and lysosomes in the gastric glandular mucosa.

MeSH terms

  • Animals
  • Anti-Ulcer Agents / pharmacology*
  • Anti-Ulcer Agents / therapeutic use
  • Carnosine* / analogs & derivatives*
  • Cell Degranulation / drug effects
  • Cell Membrane / drug effects
  • Dipeptides / pharmacology*
  • Dipeptides / therapeutic use
  • Gastric Mucosa / drug effects*
  • Glucuronidase / metabolism
  • Intracellular Membranes / drug effects
  • Liver / drug effects
  • Liver / ultrastructure
  • Lysosomes / drug effects
  • Lysosomes / enzymology
  • Male
  • Mast Cells / drug effects
  • Organometallic Compounds / pharmacology*
  • Organometallic Compounds / therapeutic use
  • Rats
  • Rats, Inbred Strains
  • Stomach Ulcer / drug therapy*
  • Stomach Ulcer / etiology
  • Stress, Physiological
  • Zinc
  • Zinc Compounds

Substances

  • Anti-Ulcer Agents
  • Dipeptides
  • Organometallic Compounds
  • Zinc Compounds
  • polaprezinc
  • Carnosine
  • Glucuronidase
  • Zinc