[Effect of enterosorption on immunologic parameters of patients with colorectal cancer in the postoperative period]

Vopr Onkol. 2009;55(1):66-71.
[Article in Russian]

Abstract

Our investigation was carried out on an assumption that end results among patients radically-treated for colorectal cancer might be improved by use of enteroabsorption. The study group included 17, controls--13 patients with diagnostically verified stage I-III tumors. Mixed sorbent (microcellulose + polysorb) (6g) was administered, once a week, on the average of 20 days after operation. Immunological vigor was assayed 3 weeks after surgery: immunoglobulin levels--by turbodimetric method, cellular profile of lymphocytes--monoclonal antibodies to cell markers CD3, CD4, CD8, CD16 and CD22. As a result of adjuvant treatment CD22 (B-lymphocytes) concentration increased significantly--from 17.70 to 21.66 (22%), while CD16 (innate killers) both in absolute numbers (19%) and by percentage points (9%). Circulating immunocomplex levels in the sorbent-treatment group were significantly lower (37.44 ths units) than in control (48 ths units) (average 28%). No relapse or metastases were reported in either group.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD / drug effects
  • B-Lymphocytes / drug effects
  • CD3 Complex / drug effects
  • CD4 Antigens / drug effects
  • CD8 Antigens / drug effects
  • Cellulose / therapeutic use*
  • Chemotherapy, Adjuvant
  • Colorectal Neoplasms / drug therapy*
  • Colorectal Neoplasms / immunology*
  • Colorectal Neoplasms / pathology
  • Colorectal Neoplasms / radiotherapy
  • Colorectal Neoplasms / surgery
  • Complement C3 / drug effects
  • Complement C4 / drug effects
  • Enterosorption*
  • Female
  • Humans
  • Immunoglobulins / drug effects
  • Killer Cells, Natural / drug effects
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Polymers / therapeutic use*
  • Radiotherapy, Adjuvant
  • Receptors, IgG / drug effects
  • Sialic Acid Binding Ig-like Lectin 2 / drug effects

Substances

  • Antigens, CD
  • CD3 Complex
  • CD4 Antigens
  • CD8 Antigens
  • Complement C3
  • Complement C4
  • Immunoglobulins
  • Polymers
  • Receptors, IgG
  • Sialic Acid Binding Ig-like Lectin 2
  • polysorb
  • Cellulose