The effect of wasabi rhizome extract on atopic dermatitis-like symptoms in HR-1 hairless mice

J Nutr Sci Vitaminol (Tokyo). 2009 Apr;55(2):195-200. doi: 10.3177/jnsv.55.195.


We investigated the effect of wasabi rhizome extract on atopic dermatitis (AD) model mice. The wasabi extract was fed to the HR-1 hairless mice, which develop AD-like symptoms with a special diet (HR-AD diet). The extract was expected to reduce the symptoms induced. Wasabi rhizome-containing HR-AD diet (5% and 10%) reduced the scratching behavior, and the 10% wasabi rhizome HR-AD diet significantly reduced scratching behavior on days 28, 35 and 42. Plasma components (histamine, eotaxin, IgE and thymus and activation-regulated chemokine (TARC)) were decreased in the 10% wasabi rhizome HR-AD diet. In histopathological examinations (toluidine blue (T.B.), major basic protein (MBP), CD4, IL-4, IL-5, eotaxin, TARC and IgE), the wasabi rhizome-containing HR-AD diet (5% and 10%) significantly reduced the number of positive stained cells. These results suggested that the wasabi rhizome extract improved the AD-like symptoms of HR-1 hairless mice.

MeSH terms

  • Animals
  • Antibodies / analysis
  • Behavior, Animal / drug effects
  • Brassicaceae*
  • Chemokine CCL17 / blood
  • Chemokines, CC / blood
  • Dermatitis, Atopic / drug therapy*
  • Disease Models, Animal
  • Energy Intake / drug effects
  • Histamine / blood
  • Immunoglobulin E / blood
  • Male
  • Mice
  • Mice, Hairless
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Pruritus / drug therapy
  • Rhizome
  • Skin / immunology*
  • Weight Gain / drug effects


  • Antibodies
  • Chemokine CCL17
  • Chemokines, CC
  • Plant Extracts
  • Immunoglobulin E
  • Histamine