Diuretic renography in hydronephrosis: renal tissue tracer transit predicts functional course and thereby need for surgery

Eur J Nucl Med Mol Imaging. 2009 Oct;36(10):1665-73. doi: 10.1007/s00259-009-1138-5. Epub 2009 May 13.


Purpose: The recognition of those hydronephrotic kidneys which require therapy to preserve renal function remains difficult. We retrospectively compared the 'tissue tracer transit' (TTT) of (99m)Tc-mercaptoacetyltriglycine ((99m)Tc-MAG(3)) with 'response to furosemide stimulation' (RFS) and with 'single kidney function < 40%' (SKF < 40%) to predict functional course and thereby need for surgery.

Methods: Fifty patients with suspected unilateral obstruction and normal contralateral kidney had 115 paired (baseline/follow-up) (99m)Tc-MAG(3) scintirenographies. Three predictions of the functional development were derived from each baseline examination: the first based on TTT (visually assessed), the second on RFS and the third on SKF < 40%. Each prediction also considered whether the patient had surgery. Possible predictions were 'better', 'worse' or 'stable' function. A comparison of SKF at baseline and follow-up verified the predictions.

Results: The frequency of correct predictions for functional improvement following surgery was 8 of 10 kidneys with delayed TTT, 9 of 22 kidneys with obstructive RFS and 9 of 21 kidneys with SKF < 40%; for functional deterioration without surgery it was 2 of 3 kidneys with delayed TTT, 3 of 20 kidneys with obstructive RFS and 3 of 23 kidneys with SKF < 40%. Without surgery 67 of 70 kidneys with timely TTT maintained function. Without surgery 0 of 9 kidneys with timely TTT but obstructive RFS and only 1 of 16 kidneys with timely TTT but SKF < 40% lost function.

Conclusion: Delayed TTT appears to identify the need for therapy to preserve function of hydronephrotic kidneys, while timely TTT may exclude risk even in the presence of an obstructive RFS or SKF < 40%.

Publication types

  • Comment

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Diuretics
  • Female
  • Furosemide
  • Humans
  • Hydronephrosis / diagnostic imaging*
  • Hydronephrosis / physiopathology
  • Hydronephrosis / surgery
  • Infant
  • Infant, Newborn
  • Kidney Function Tests / methods
  • Male
  • Middle Aged
  • Models, Biological
  • Radioisotope Renography / methods*
  • Radiopharmaceuticals
  • Retrospective Studies
  • Risk Factors
  • Technetium Tc 99m Mertiatide
  • Young Adult


  • Diuretics
  • Radiopharmaceuticals
  • Technetium Tc 99m Mertiatide
  • Furosemide