Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 51 (1), 23-33

Malassezia Species and Seborrheic Dermatitis

  • PMID: 19437895

Malassezia Species and Seborrheic Dermatitis

Lilia G Zisova. Folia Med (Plovdiv).


Malassezia spp. are medically important dimorphic, lipophilic yeasts that form part of the normal cutaneous microflora of human. Seborrheic dermatitis is a multifactor disease that needs endogenous and exogenous predisposing factors for its development. Presence of these factors leads to reproduction of the saprophytic opportunistic pathogen Malassezia spp. and development of a disease. The inflammatory reaction against the yeast Malassezia is considered basic in the etiology of the seborrheic dermatitis. The pathogenesis and exact mechanisms via which these yeasts cause inflammation are still not fully elucidated. They are rather complex and subject of controversy in literature. Most probably Malassezia spp. cause seborrheic dermatitis by involving and combining both nonummune and immune mechanisms (nonspecific and specific). Which of these mechanisms will dominate in any single case depends on the number and virulence of the yeasts as well as on the microorganism reactivity. In the recent years a great interest have been aroused by the epidemiological investigations. Depending on the geographical place of the countries different Malassezia species in seborrheic dermatitis dominate in the different countries. In view of the etiology and pathogenesis of the seborrheic dermatitis comprehensive antifungal preparations have been recently introduced and are nowadays the basic therapeutic resource in the treatment of this disease.

Similar articles

  • Seborrheic Dermatitis of the Scalp: Etiology and Treatment
    AK Gupta et al. J Drugs Dermatol 3 (2), 155-8. PMID 15098970.
    Seborrheic dermatitis is a common chronic infection of the lipid-rich areas of skin. While seborrheic dermatitis has been a recognized clinical entity for decades, its et …
  • A Pilot Study on Seborrheic Dermatitis Using Pramiconazole as a Potent Oral anti-Malassezia Agent
    GE Piérard et al. Dermatology 214 (2), 162-9. PMID 17341867. - Clinical Trial
    A single 200-mg dose of pramiconazole appears to abate seborrheic dermatitis. The density in Malassezia present on lesional skin is first decreased, followed by clearing …
  • Seborrheic Dermatitis
    AK Gupta et al. Dermatol Clin 21 (3), 401-12. PMID 12956195. - Review
    Seborrheic dermatitis is present in 1% to 3% of immunocompetent adults, and is more prevalent in men than in women. Seborrheic dermatitis may be seen in conjunction with …
  • Seborrheic Dermatitis
    AK Gupta et al. J Eur Acad Dermatol Venereol 18 (1), 13-26; quiz 19-20. PMID 14678527. - Review
    Upon completing this paper, the reader should be aware of the clinical presentation of seborrheic dermatitis and which populations are at particular risk of developing th …
  • Role of Antifungal Agents in the Treatment of Seborrheic Dermatitis
    AK Gupta et al. Am J Clin Dermatol 5 (6), 417-22. PMID 15663338. - Review
    Seborrheic dermatitis is a superficial fungal disease of the skin, occurring in areas rich in sebaceous glands. It is thought that an association exists between Malassezi …
See all similar articles

Cited by 4 PubMed Central articles


LinkOut - more resources