Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 52 (13), 4063-7

Discovery of Low Nanomolar and Subnanomolar Inhibitors of the Mycobacterial Beta-Carbonic Anhydrases Rv1284 and Rv3273

Affiliations

Discovery of Low Nanomolar and Subnanomolar Inhibitors of the Mycobacterial Beta-Carbonic Anhydrases Rv1284 and Rv3273

Ozlen Güzel et al. J Med Chem.

Abstract

A series of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides has been derivatized by reaction with 2,4,6-trimethylpyrylium perchlorate, leading to pyridinium derivatives. The new sulfonamides were evaluated as inhibitors of two beta-carbonic anhydrases (CAs, EC 4.2.1.1) from Mycobacterium tuberculosis, Rv1284 and Rv3273. The whole series showed excellent nanomolar inhibitory activity, with several subnanomolar inhibitors being detected. Rv1284 and Rv3273 have potential for developing antimycobacterial agents with an alternate mechanism of action.

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback