Signaling pathways regulating zebrafish lateral line development

Curr Biol. 2009 May 12;19(9):R381-6. doi: 10.1016/j.cub.2009.03.057.

Abstract

The lateral line organ is a mechanosensory organ of fish and amphibians that detects changes in water flow. The lateral line organ of zebrafish has been used as a model for cell polarity and collective cell migration as well as hair cell loss and regeneration. A combination of genetic tools and live imaging has allowed dissection of signaling pathways that regulate these processes. Here, we summarize recent findings on the roles of the FGF, Wnt/beta-catenin, and Notch pathways in the initial formation of the posterior lateral line primordium, as well as during organ patterning, migration, cell fate specification and hair cell regeneration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology*
  • Cell Movement / physiology*
  • Fibroblast Growth Factors / metabolism
  • Lateral Line System / embryology*
  • Lateral Line System / metabolism*
  • Morphogenesis / physiology*
  • Receptors, Notch / metabolism
  • Signal Transduction / physiology*
  • Wnt Proteins / metabolism
  • Zebrafish / embryology*
  • beta Catenin / metabolism

Substances

  • Receptors, Notch
  • Wnt Proteins
  • beta Catenin
  • Fibroblast Growth Factors