Diphosphoinositol polyphosphates: metabolic messengers?

Mol Pharmacol. 2009 Aug;76(2):236-52. doi: 10.1124/mol.109.055897. Epub 2009 May 13.


The diphosphoinositol polyphosphates ("inositol pyrophosphates") are a specialized subgroup of the inositol phosphate signaling family. This review proposes that many of the current data concerning the metabolic turnover and biological effects of the diphosphoinositol polyphosphates are linked by a common theme: these polyphosphates act as metabolic messengers. This review will also discuss the latest proposals concerning possible molecular mechanisms of action of this intriguing class of molecules.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Inositol Phosphates / chemistry
  • Inositol Phosphates / metabolism*
  • Molecular Structure
  • Polyphosphates / metabolism*
  • Signal Transduction


  • Inositol Phosphates
  • Polyphosphates