New concepts in breast cancer emerge from analyzing clinical data using numerical algorithms

Int J Environ Res Public Health. 2009 Jan;6(1):329-48. doi: 10.3390/ijerph6010347. Epub 2009 Jan 20.


A small international group has recently challenged fundamental concepts in breast cancer. As a guiding principle in therapy, it has long been assumed that breast cancer growth is continuous. However, this group suggests tumor growth commonly includes extended periods of quasi-stable dormancy. Furthermore, surgery to remove the primary tumor often awakens distant dormant micrometastases. Accordingly, over half of all relapses in breast cancer are accelerated in this manner. This paper describes how a numerical algorithm was used to come to these conclusions. Based on these findings, a dormancy preservation therapy is proposed.

Keywords: Breast cancer; dormancy preservation therapy; quasi-stable dormancy; surgery-induced angiogenesis.

MeSH terms

  • Algorithms
  • Biomedical Research
  • Breast / pathology*
  • Breast Neoplasms / etiology
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / therapy
  • Female
  • Humans
  • Mastectomy / adverse effects*
  • Models, Biological*
  • Neoplasm Metastasis
  • Recurrence