CE-TOF/MS: fundamental concepts, instrumental considerations and applications

Electrophoresis. 2009 May;30(10):1610-23. doi: 10.1002/elps.200800782.


This review discusses the fundamental principles of TOF analyzers and covers the great progress that has been made in this area in recent years (i.e. orthogonal acceleration, reflectron). This paper also gives an overview of applications performed by CE coupled to TOF/MS detection. The main domains of interest include the analysis of biomolecules and natural compounds.

Publication types

  • Review

MeSH terms

  • Electrophoresis, Capillary / instrumentation*
  • Electrophoresis, Capillary / methods*
  • Mass Spectrometry / instrumentation*
  • Mass Spectrometry / methods*
  • Proteomics / methods
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization