The complex relationship between magnesium and serum parathyroid hormone: a study in patients with chronic intestinal failure

Magnes Res. 2009 Mar;22(1):37-43.


In this study we compared the content of muscle free [Mg2+] assessed by 31P MRS to that of serum total Mg assessed by routine colorimetric assays in 15 patients affected by Chronic Intestinal Failure (CIF) on long-term Home Parenteral Nutrition (HPN) or who had undergone isolated intestinal transplantation. We also investigated in the same cohort of patients the relationship of muscle free [Mg2+] and serum total Mg with parathyroid hormone (PTH) serum content. All patients showed a normal cytosolic free [Mg2+] in the calf muscle despite about half of them having a content of total serum [Mg] below or at the lower edge of the boundary limits. Muscle free Mg2+ and serum total Mg displayed an opposite correlation versus serum PTH, showing that the intracellular free form possesses a different functional metabolic meaning in the regulation of PTH secretion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chronic Disease
  • Female
  • Humans
  • Intestinal Diseases / metabolism*
  • Intestines / transplantation
  • Magnesium / blood*
  • Magnesium / metabolism*
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Multiple Organ Failure / metabolism
  • Muscle, Skeletal / metabolism
  • Parathyroid Hormone / blood*
  • Parenteral Nutrition, Home / adverse effects


  • Parathyroid Hormone
  • Magnesium