ING proteins in cellular senescence

Curr Drug Targets. 2009 May;10(5):406-17. doi: 10.2174/138945009788185077.


Cellular senescence is an effective anti-tumor barrier that acts by restraining the uncontrolled proliferation of cells carrying potentially oncogenic alterations. ING proteins are putative tumor suppressor proteins functionally linked to the p53 pathway and to chromatin regulation. ING proteins exert their tumor-protective action through different types of responses. Here, we review the evidence on the participation of ING proteins, mainly ING1 and ING2, in the implementation of the senescent response. The currently available data support an important role of ING proteins as regulators of senescence, in connection with the p53 pathway and chromatin organization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Proliferation
  • Cellular Senescence / physiology*
  • Chromatin / metabolism
  • Humans
  • Neoplasms / metabolism
  • Tumor Suppressor Protein p53 / metabolism*
  • Tumor Suppressor Proteins / metabolism*


  • Chromatin
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins