SELDI protein chip technology for the detection of serum biomarkers for liver disease

Protein Pept Lett. 2009;16(5):467-72. doi: 10.2174/092986609788167851.


The need to identify disease biomarkers is critical to ensure fast diagnosis and timely treatment. Surface enhanced laser desorption/ionization time-of-fight mass spectrometry (SELDI-TOF-MS) is a widely used technology platform for diagnostic biomarker discovery. This short review provides an overview of how it functions and also describes its advantages and drawbacks.

Publication types

  • Review

MeSH terms

  • Biomarkers / blood
  • Blood Chemical Analysis / instrumentation
  • Blood Chemical Analysis / methods*
  • Humans
  • Liver Diseases / blood*
  • Mass Spectrometry / instrumentation
  • Mass Spectrometry / methods*
  • Protein Array Analysis / instrumentation
  • Protein Array Analysis / methods*
  • Surface Properties


  • Biomarkers