Biomarkers for early detection of liver cancer: focus on clinical evaluation

Protein Pept Lett. 2009;16(5):473-8. doi: 10.2174/092986609788167888.


This review summarises the screening methods from hepatic ultrasonography to serological biomarkers for early detection of liver cancer and focuses on evaluation of biomarkers ability. The development of novel biomarkers according to the 5-phase program defined by the Early Detection Research Network (EDRN) is also outlined in this review.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / blood
  • Biomarkers, Tumor / metabolism
  • Diagnostic Imaging
  • Early Detection of Cancer*
  • Humans
  • Liver Neoplasms / blood
  • Liver Neoplasms / diagnosis*
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / metabolism*
  • Radiography
  • Serologic Tests


  • Biomarkers, Tumor