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. 1991 Jan;256(1):59-66.
doi: 10.1016/0921-8734(91)90034-9.

Reduced DNA Repair in Progeria Cells and Effects of Gamma-Ray Irradiation on UV-induced Unscheduled DNA Synthesis in Normal and Progeria Cells

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Reduced DNA Repair in Progeria Cells and Effects of Gamma-Ray Irradiation on UV-induced Unscheduled DNA Synthesis in Normal and Progeria Cells

S M Wang et al. Mutat Res. .

Abstract

A reduction in the amount of UV-induced unscheduled DNA synthesis (UDS), and reduced cell survival and host-cell reactivation against UV exposure in Hutchinson-Gilford progeria syndrome cell strains were shown. UV-induced UDS in 4 progeria cell strains was 33-50% of the normal level. A similar reduction in the UV-induced UDS in normal cells was caused by gamma-ray irradiation to the cells before UV irradiation. The dose of gamma-rays required to cause a reduction in UDS of normal cells to the level of progeria cells was 40 Gy and the reduction was reversible after 2 days. In progeria cells, gamma-ray irradiation further reduced UDS with a lower gamma-ray dose required than in normal cells, and the reduction was also reversible but with less relative recovery than in normal cells. The presence of a 'built-in' defect in progeria cells responsible for the reduced DNA-repair capacity was suggested, and such defect may share a common mechanism with the reduction of UV-induced UDS in normal cells caused by gamma-ray irradiation.

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  • Hutchinson-Guilford progeria syndrome.
    Sarkar PK, Shinton RA. Sarkar PK, et al. Postgrad Med J. 2001 May;77(907):312-7. doi: 10.1136/pmj.77.907.312. Postgrad Med J. 2001. PMID: 11320273 Free PMC article. Review. No abstract available.

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