Chronic multifocal demyelinating neuropathy associated with central nervous system demyelination

Muscle Nerve. 1991 Oct;14(10):953-9. doi: 10.1002/mus.880141005.


We have carried out a long-term study of lesions found in a man who had a demyelinating disease of both central and peripheral nervous systems. During the 10 years of his clinical course, he suffered from optic neuritis, multifocal myelitis, and chronic multifocal demyelinating neuropathy, with persistent conduction block. Our study revealed that both central and peripheral nervous system demyelination occurred repeatedly and simultaneously.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chronic Disease
  • Demyelinating Diseases / diagnosis*
  • Demyelinating Diseases / drug therapy
  • Demyelinating Diseases / physiopathology
  • Electromyography
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Methylprednisolone / therapeutic use
  • Neural Conduction / physiology
  • Prednisolone / therapeutic use
  • Recurrence
  • Spinal Cord / pathology


  • Prednisolone
  • Methylprednisolone