Determination of nerve conduction abnormalities in patients with impaired glucose tolerance

Neurol Sci. 2009 Aug;30(4):281-9. doi: 10.1007/s10072-009-0089-8. Epub 2009 May 15.


Recent studies have shown that impaired glucose tolerance (IGT) is associated with dysfunction in the peripheral and autonomic nerves. The aim of this study was to determine the electrophysiological abnormalities of IGT. To determine electrophysiological abnormality in the large sensorimotor and sudomotor autonomic nerves with IGT patients, 43 patients and 34 healthy subjects have been studied. Subjective neuropathy symptoms, neurological examination and the electrophysiological findings were evaluated. When conduction of large somatic fibers only was evaluated, the ratio of electrophysiological abnormality was found to be 21%. In addition, where sympathetic skin response was evaluated the sudomotor autonomic abnormality ratio was 28% in upper extremities, 53% in lower extremities, and 16% in upper and lower extremities together. The percentages of abnormal electrophysiological parameters in different motor and sensory nerves were 39.5% in the peroneal motor nerve, 20.9% in the median motor and sural sensory nerves, 18.6% in the median sensory nerve, 16.3% in the tibial motor nerve, 14% in the ulnar sensory nerve, and 2.3% in the ulnar motor nerve. While distal motor latency was the most frequent abnormal parameter in the median and tibial motor nerves, the amplitude changes in the peroneal and ulnar motor nerves were also prominent. In sensory evaluation, the onset latency in the median-ulnar sensory nerves and the amplitude in the sural sensory nerve were found to be evident abnormalities.

MeSH terms

  • Action Potentials / physiology
  • Adult
  • Aged
  • Aged, 80 and over
  • Electric Stimulation
  • Electrophysiological Phenomena
  • Female
  • Glucose Intolerance / physiopathology*
  • Glucose Tolerance Test
  • Humans
  • Male
  • Middle Aged
  • Motor Neurons / physiology
  • Nerve Fibers / physiology
  • Neural Conduction / physiology*
  • Neurologic Examination / methods*
  • Peripheral Nerves / physiopathology
  • Polyneuropathies / diagnosis
  • Young Adult