Perilla leaf extract ameliorates obesity and dyslipidemia induced by high-fat diet

Phytother Res. 2009 Dec;23(12):1685-90. doi: 10.1002/ptr.2811.


The objective of this study was to evaluate the antiobesity effect of perilla leaf extract (PLE) in animal models of high fat diet-induced obesity. C57BL/6J mice were fed a standard diet (STD) or high fat diet (HFD) for 5 weeks to induce obesity. The experimental groups were four groups with 10 mice per group and fed for 4 weeks: a STD group, a HFD group, a HFD containing 1% PLE (HFD+PLE 1%) group and a HFD containing 3% PLE (HFD+PLE 3%) group. The PLE supplementation significantly decreased body weight gain, food efficiency ratio, and relative liver and epididymal fat mass compared with those of the HFD group. Also, triglyceride, total cholesterol and LDL levels in the plasma were significantly reduced by PLE supplementation compared with the HFD group. Histological changes in the liver of the PLE supplemented group showed an inhibition of steatosis induced by HFD. Furthermore, PLE reversed the HFD induced changes in the expression patterns of epididymal adipose tissue genes: acetyl CoA carboxylase (ACC), glycerol-3-phosphate dehydrogenase (GPDH) and peroxisome proliferator-activated receptor gamma (PPARgamma). These results suggest that the PLE supplement suppressed body weight gain and improved the blood lipid profiling, in part by down-regulating adipogenic transcription factor and other specific target genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetyl-CoA Carboxylase / metabolism
  • Adipose Tissue / drug effects
  • Animals
  • Anti-Obesity Agents / pharmacology
  • Anti-Obesity Agents / therapeutic use*
  • Cholesterol, LDL / blood
  • Diet
  • Dietary Fats / adverse effects*
  • Dyslipidemias / drug therapy*
  • Gene Expression Regulation
  • Glycerolphosphate Dehydrogenase / metabolism
  • Liver / drug effects
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity / drug therapy*
  • PPAR gamma / metabolism
  • Perilla / chemistry*
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Leaves / chemistry
  • Triglycerides / blood
  • Weight Gain / drug effects


  • Anti-Obesity Agents
  • Cholesterol, LDL
  • Dietary Fats
  • PPAR gamma
  • Plant Extracts
  • Triglycerides
  • Glycerolphosphate Dehydrogenase
  • Acetyl-CoA Carboxylase