Fundamentals and health benefits of xanthohumol, a natural product derived from hops and beer

Nat Prod Commun. 2009 May;4(5):591-610.


In recent years, there has been a growing interest in phenolic compounds and their presumed role in the prevention of various degenerative diseases, such as cancer and cardiovascular diseases. Xanthohumol, a prenylated chalcone from hops and beer, is among the phenolic compounds which have received the most attention in recent years. This compound has a range of interesting biological properties that may have therapeutic utility. Based on the health-promoting properties of xanthohumol, the production of a beer enriched in this substance would be of huge interest to the brewing industry, for the benefits this could bring to consumer's health. This paper reviews recent and important data with respect to the health benefits or biological activities of xanthohumol and beer. In addition, an overview of the chemistry and biotechnological aspects of xanthohumol is presented.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Beer*
  • Cytostatic Agents / chemistry
  • Cytostatic Agents / isolation & purification
  • Cytostatic Agents / pharmacology*
  • Fermentation
  • Flavonoids
  • Food Handling / methods
  • Humulus / chemistry*
  • Plant Extracts / chemistry
  • Propiophenones / chemistry
  • Propiophenones / isolation & purification
  • Propiophenones / pharmacology*


  • Anti-Infective Agents
  • Antioxidants
  • Cytostatic Agents
  • Flavonoids
  • Plant Extracts
  • Propiophenones
  • xanthohumol