Abstract
The induction of heat-shock transcription factor (HSF) binding to DNA is accomplished by a heat-induced oligomerization. The transition to the induced state is accompanied by a chromosomal redistribution of HSF to the heat-shock puff sites. Over 150 additional chromosomal sites also accumulate HSF, including developmental loci that are repressed during heat shock. These findings suggest an unforeseen role for HSF as a repressor of normal gene activity during heat stress.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Binding Sites
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Cell Nucleus / physiology
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Chromosomes / physiology*
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Chromosomes / ultrastructure
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DNA / metabolism
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism*
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Drosophila / genetics*
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Heat Shock Transcription Factors
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Hot Temperature
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Macromolecular Substances
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Protein Binding
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Transcription Factors / metabolism*
Substances
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DNA-Binding Proteins
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Heat Shock Transcription Factors
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Macromolecular Substances
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Transcription Factors
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DNA