Stress-induced oligomerization and chromosomal relocalization of heat-shock factor

Nature. 1991 Oct 31;353(6347):822-7. doi: 10.1038/353822a0.


The induction of heat-shock transcription factor (HSF) binding to DNA is accomplished by a heat-induced oligomerization. The transition to the induced state is accompanied by a chromosomal redistribution of HSF to the heat-shock puff sites. Over 150 additional chromosomal sites also accumulate HSF, including developmental loci that are repressed during heat shock. These findings suggest an unforeseen role for HSF as a repressor of normal gene activity during heat stress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding Sites
  • Cell Nucleus / physiology
  • Chromosomes / physiology*
  • Chromosomes / ultrastructure
  • DNA / metabolism
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism*
  • Drosophila / genetics*
  • Heat Shock Transcription Factors
  • Hot Temperature
  • Macromolecular Substances
  • Protein Binding
  • Transcription Factors / metabolism*


  • DNA-Binding Proteins
  • Heat Shock Transcription Factors
  • Macromolecular Substances
  • Transcription Factors
  • DNA