Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men

J Urol. 2009 Jul;182(1):237-48. doi: 10.1016/j.juro.2009.02.121. Epub 2009 May 17.


Purpose: We determined the efficacy of coenzyme Q10 supplementation on semen parameters, sperm function and reproductive hormone profiles in infertile men.

Materials and methods: A total of 212 infertile men with idiopathic oligoasthenoteratospermia were randomly assigned to receive 300 mg coenzyme Q10 (Kaneka, Osaka, Japan) orally daily (106 in group 1) or a similar placebo regimen (106 in group 2) during a 26-week period, followed by a 30-week treatment-free phase. Two semen analyses, acrosome reaction test, immunobead test for antisperm antibody, and determination of resting levels of luteinizing hormone, follicle-stimulating hormone, prolactin, testosterone and inhibin B were done in all participants. Blood and seminal plasma total coenzyme Q10 was also assessed.

Results: Significant improvement in sperm density and motility was evident with coenzyme Q10 therapy (each p = 0.01). Using the Kruger classification sperm morphology evaluation revealed an increase in the percent of normal forms in the coenzyme Q10 group (p = 0.07). A positive correlation was found between treatment duration with coenzyme Q10 and sperm count (r = 0.46, p = 0.03) as well as with sperm motility (r = 0.45, p = 0.04) and sperm morphology (r = 0.34, p = 0.04). The coenzyme Q10 group had a significant decrease in serum follicle-stimulating hormone and luteinizing hormone at the 26-week treatment phase (each p = 0.03). By the end of the treatment phase the mean +/- SD acrosome reaction had increased from 14% +/- 8% and 15% +/- 8% to 31% +/- 11% and 16% +/- 10% in the coenzyme Q10 and placebo groups, respectively (p = 0.01).

Conclusions: Coenzyme Q10 supplementation resulted in a statistically significant improvement in certain semen parameters. However, further studies are needed to draw a final conclusion and evaluate the effect of coenzyme Q10 supplementation on the pregnancy rate.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Dietary Supplements*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Follow-Up Studies
  • Humans
  • Infertility, Male / diagnosis
  • Infertility, Male / drug therapy*
  • Male
  • Oligospermia / diagnosis
  • Oligospermia / drug therapy
  • Probability
  • Reference Values
  • Risk Assessment
  • Semen / drug effects*
  • Semen / metabolism
  • Semen Analysis
  • Sperm Count
  • Spermatozoa / drug effects*
  • Treatment Outcome
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / therapeutic use
  • Young Adult


  • Ubiquinone
  • coenzyme Q10