Endocytic regulation of Notch signaling

Curr Opin Genet Dev. 2009 Aug;19(4):323-8. doi: 10.1016/j.gde.2009.04.005. Epub 2009 May 15.


Endocytosis and endosomal trafficking have emerged as important cell biological steps in the Notch developmental signaling pathway. Ligand endocytosis helps generate the physical forces needed to dissociate and activate the receptor, and activated receptors enter endosomes to signal productively. Endosomal trafficking is also responsible for downregulating Notch receptors that have not been activated by ligand. Recent studies have provided new insights into these Notch trafficking steps, and have uncovered additional endosomal mechanisms that contribute to asymmetric Notch activation and ligand-independent Notch signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endocytosis / physiology*
  • Endosomes / metabolism
  • Models, Biological
  • Protein Transport / physiology
  • Receptors, Notch / metabolism*
  • Receptors, Notch / physiology
  • Signal Transduction / physiology


  • Receptors, Notch