Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration

Cell Cycle. 2009 Jun 15;8(12):1883-7. doi: 10.4161/cc.8.12.8815. Epub 2009 Jun 21.

Abstract

Here I overview the accompanying three reports on suppression of cellular senescence with inhibitors of mTOR, PI-3K and MEK. How can growth inhibitors suppress senescence? May these aging-suppressants decelerate organismal aging? To answer these questions, we need to reconsider the meaning of aging.

MeSH terms

  • Animals
  • Caloric Restriction
  • Cell Cycle / drug effects
  • Cell Cycle / physiology
  • Cellular Senescence / drug effects*
  • Cellular Senescence / physiology
  • Humans
  • Longevity / drug effects*
  • Longevity / physiology
  • MAP Kinase Kinase Kinases / antagonists & inhibitors
  • MAP Kinase Kinase Kinases / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphoinositide-3 Kinase Inhibitors
  • Protein Kinases / drug effects
  • Protein Kinases / metabolism*
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Sirolimus / pharmacology*
  • TOR Serine-Threonine Kinases

Substances

  • Phosphoinositide-3 Kinase Inhibitors
  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • MAP Kinase Kinase Kinases
  • Sirolimus