Loci at chromosomes 13, 19 and 20 influence age at natural menopause

Nat Genet. 2009 Jun;41(6):645-7. doi: 10.1038/ng.387. Epub 2009 May 17.

Abstract

We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Breast Neoplasms / genetics
  • Cardiovascular Diseases / genetics
  • Chromosomes, Human, Pair 13 / genetics*
  • Chromosomes, Human, Pair 19 / genetics*
  • Chromosomes, Human, Pair 20 / genetics*
  • European Continental Ancestry Group / genetics
  • Female
  • Genetic Variation
  • Genome-Wide Association Study*
  • Humans
  • Menopause / genetics*
  • Meta-Analysis as Topic
  • Middle Aged
  • Odds Ratio
  • Osteoporosis / genetics
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Twin Studies as Topic